So I'm left handed and curious.
I usually place the mouse to the left of my (regular) keyboard
and use the arrow keys for movement with my right. Using the
G400 Logitech mouse, and mapped buttons to weapons ect..
Been using this in every game since the early days of Duke
Nukem 1 and comes natural.
For surfing and at work I use it right handed. Ya
its different, but works for me. I throw right
and write left.
If your left handed, whats your setup?
Do you see it as a disadvantage when playing?